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1. CSB
2. Publications
Paper April 2024

neutrality have clear and informative effects on the entropy’s behaviour over time. Analysis of publicly available data of a natural D. melanogaster population, that had been sampled over seven years, using [...] a quantity related to entropy, that we term pseudoentropy . This quantity emerges in a diffusion analysis of the mean time a mutation segregates in a population. For a neutral locus with an arbitrary number [...] of positive selection on genome-wide diversity over short time scales. https://doi.org/10.1016/j.biosystems.2024.105176 © Nikolas Vellnow/CSB © Nikolas Vellnow/CSB …
1. TU Dortmund
2. University
Prof. Alexander Marx

Causality, since 1 June 2024 To the Professorship Department: Statistics, Research Center for Trustworthy Data Science and Security Studies and doctorate: 2021: Doctorate in Computer Science, Max Planck Institute [...] Bioinformatics, Saarland University © ETH Zürich / Nicola Pitaro Stages: 2024: Postdoc, Department of Biosystems Science and Engineering, ETH Zurich 2021-2023: Postdoc-Fellow, Department of Computer Science and …
1. Genetik
Research

Statistical analysis of gene expression data Statistical analysis of clinical data Survival analysis (analysis of event times) Specific current research topics include: Statistical analysis of genomic data from [...] Statistical analysis of genomic data for cancer diagnosis and therapy Methods for biological interpretation of gene expression data Statistical analysis of data from proteomics Analysis of methods for [...] for variable selection Analysis of large text collections using topic modeling …
1. IPS
2. News: 8/13/2021
AKKORD: Integration and visualization through modular data analysis

this purpose: Data access modules Analysis modules Result modules Data access modules fulfill tasks for data connection and ensure consistent, efficient access to the necessary analysis data. Preconfigurable [...] will provide support for the efficient implementation of analysis modules in industrial processes. In this way, barriers to the use of data analysis technology are to be lowered, particularly for non-res [...] The visualization modules fulfill the following functions: Data selection: Alternative connection of available data sources. Predefined data sources can be replaced temporarily or permanently by the Dashboard …
1. GRK 2624
2. Research
3. Projects
I4: Omics-LongInt

Integrative analysis of longitudinal omics data In project I4, statistical methods will be developed for the integrative analysis of omics data (e.g., genomic, transcriptomic, and proteomic data) collected [...] allows a direct analysis of the influence of the different data types together in a multivariate way. This coefficient, which has originally been developed for the analysis of two data types, was embedded [...] These expression data will be analysed integratively in this project. Our starting point for the development of statistical methods for the integrative analysis of such longitudinal omics data is the externally …
1. dbis
2. Publications
3. 2017
Efficient Storage and Analysis of Genome Data in Database

Efficient Storage and Analysis of Genome Data in Databases Title Efficient Storage and Analysis of Genome Data in Databases Authors Sebastian Dorok, Sebastian Breß, Jens Teubner, Horstfried Läpple, Gunter [...] Genome-analysis enables researchers to detect mutations within genomes and deduce their consequences. Researchers need reliable analysis platforms to ensure reproducible and comprehensive analysis results [...] the complete genome-analysis process, because (1) database systems suffer from high storage overhead for genome data and (2) they introduce overhead during domain-specific analysis. To overcome these …
1. dbis
2. Publications
3. 2017
Efficiently Storing and Analyzing Genome Data in Database

Efficiently Storing and Analyzing Genome Data in Database Systems Title Efficient Storage and Analysis of Genome Data in Databases Authors Sebastian Dorok, Sebastian Breß, Jens Teubner, Horstfried Läpple [...] Genome-analysis enables researchers to detect mutations within genomes and deduce their consequences. Researchers need reliable analysis platforms to ensure reproducible and comprehensive analysis results [...] the complete genome-analysis process, because (1) database systems suffer from high storage overhead for genome data and (2) they introduce overhead during domain-specific analysis. To overcome these …
1. UB
2. Research & Publishing
3. Publication Support
Text and Data Mining (TDM)

TDM? Text and data mining (TDM) refers to the automated analysis of (large) amounts of texts or other data with regard to a specific question. Computer-aided methods are used to examine a data set, for example [...] Preparation of the data The preparation of the data includes, among other things, the creation of machine readability, the structuring and normalization of the data, and the compilation of the data into a corpus [...] access (concerns the acquisition of the data) Questions of making the data accessible (concerns the transfer or sharing of data) Questions about preservation of data (concerns archiving of the corpus) Questions …
1. ellph
ELLpH - Research methods

combination with the analysis of the NEPS data, enables a comprehensive analysis using multivariate methods , supplemented by causal analyses with longitudinal data . The analysis of document and website [...] course of the project. Data collection The research program of our joint project promotes close cooperation between all three sub-projects in collection and analysis of the data. © ELLpH Document analyses [...] from different perspectives. The variety of data collected will, in turn, allow for a mutual validation of the results and data triangulation . The analysis of interviews with experts and deans of studies …
1. GRK 2624
2. Research
Projects

(Ickstadt, Cadenas) I3 Enrichment analysis for multiple data sources and complex statistical designs (Rahnenführer, Cadenas) I4 Integrative analysis of longitudinal omics data (Schwender, Hengstler) I5 Integration [...] expression and time-to-event data (Möllenhoff, Hengstler, Ghallab ) P10 Design and analysis of mixture-toxicity experiments (Schorning, Hengstler) P11 Design and analysis of complex concentration-response [...] ion of toxicological effects through appropriate integration of data, models, and results. For data integration, various molecular data sources will be combined and additional biological knowledge will …

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